2009 Combined IAAM-AsTeC Workshop - November 16, 2009
Diagnostics of Invasive Aspergillosis: From Experimental Models to Clinical Evaluation
Combined IAAM and AsTeC Workshop
November 16, 2009,
8:30 AM to 5:00 PM
WORKSHOP AGENDA
Click on the highlighted presenter names for presentation details
- Welcome and Greetings by NIAID (Dennis Dixon, Rory Duncan, Alec Ritchie)
- AsTeC and IAAM Project overview (Tom Patterson and John Wingard)
- Preclinical studies and the transition to Clinical
- Animal Models and their Utility
- Non-neutropenic animal models of IPA (Scott Filler,Laura Najvar, and Peter Warn)
- Colonization model (Don Sheppard)
- Utility of serial markers in serum, blood and BAL fluid (Nathan Wiederhold)
- Diagnostic Markers of Infection - Pre-clinical Experience
- European PCR standardization process overview (Lewis White)
- Standardization of PCR Methodologies (Brian Wickes and Monica Herrera)
- Selected New Diagnostic Targets and Methods
- Urinary Lateral Flow Device (Kieren Marr)
- Multiplexed Microbead Array Detection of Aspergillosis and Other Invasive Fungi (Frank Merante)
- Detection of Proteolytic Activity for Diagnostics (Amit Galande)
- Immunoassay for Diagnostics (Tom Kozel)
- Aspergillus Antibody Detection (David Denning and Neil Clancy)
- Characterization, Identification, and Comparative Proteomic Kinetics of Innate Host Defense Proteins in Experimental IPA and Pseudomonas Pneumonia (Tom Walsh)
- Gene Expression for Diagnostics: Experience with respiratory viruses (Aimee Zaas)
- Overview of the AsTeC: Progress to Date (John Wingard)
- Pre-IDE Submission (Barbara Alexander)
- Developing a Calibrator for Aspergillus Diagnostics
- The need and approach: lessons learned from other pathogens and the AsTeC/IAAM plan for developing a calibrator for Aspergillus (Angie Caliendo)
- Contamination/Stability Testing (David Denning)
- AsTeC Case Adjudication (Lindsey Baden)
- Manufacturer Application Process (Joe Wheat)
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Panel Discussion plus Q&A
- Moderators: Tom Patterson, John Wingard
- Panel: Barbara Alexander, Angie Caliendo, Kieren Marr, Lewis White, Brian Wickes, Aimee Zaas, Freddie Poole
- Conclusions: Next steps, Q & A (Tom Patterson, John Wingard)
